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HT-1080 cells were transfected with Ex4a(+)WT1 isoform or Mock, and analyzed for apoptosis and mitochondrial damages (Fig 6A). Ex4a(+)WT1 isoform noticeably induced apoptosis and mitochondrial membrane possible (MMP) loss in HT-1080 cells. Future, the function in the endogenous Ex4a(+)WT1 isoform in apoptosis was examined. K562 cells were treated with Doxorubicin (Dox) and apoptosis was induced. T
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F29* CAST* CCDC88A* CCNG2 CD274* CXCL16 DENND1B* DOCK11* EGR1 ETS1* FOXN3 GADD45A GADD45B HCP5* HIST1H2AE HIST1H2BG* HIST1H3D* HPSE* ICAM1/CD54 IL15* JUN LTB*UP UP UP UP UP UP DOWN DOWN UP DOWN UP UP UP UP DOWN UP DOWN DOWN UP DOWN DOWN DOWN UP UP UP DOWN UPAs a result, we delineated several groups of genes under the TUSC2 control. Interestingly, genes involved in chromatin modulation, nucleosome
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